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Dengue Fever Antigen NS1, IgG & IgM

Dengue Fever Antigen NS1, IgG & IgM Includes 3 testsView All

₹1800

You need to provide

Blood

This test is for

Male, Female

Test Preparation

No special preparation required

Understanding Dengue Fever Antigen NS1, IgG & IgM

What is Dengue Fever Antigen NS1, IgG & IgM?

Dengue Antigen NS1, IgG and IgM test detects the non-structural protein component (NS1) of the dengue virus and the antibodies (IgG & IgM) produced by the body in response to the infection. NS1 and IgM is secreted into the blood during dengue infection and are detectable within 3-4 days of illness. Therefore this test helps in early diagnosis and treatment of dengue infection. IgG antibodies appear after 14th day of infection and persist for life.
The initial symptoms which are commonly seen in dengue include sudden high fever, fatigue and flu-like symptoms.
If left untreated the infection may progress to a severe forms such as Dengue hemorrhagic fever or Dengue shock syndrome.

What is Dengue Fever Antigen NS1, IgG & IgM used for?

The Dengue Antigen NS1, IgG & IgM test is done in case there is high fever within 2 weeks of travel to an area where dengue outbreak is occurring or dengue fever is endemic.

What does Dengue Fever Antigen NS1, IgG & IgM measure?

Contains 3 tests

Dengue Fever NS1 Antigen

The Dengue Fever NS1 Antigen test measures the NS-1 protein of the dengue virus. This protein is secreted into the blood during the infection; hence, it can only be detected during the early stages of the illness. It is recommended to do the Dengue Fever NS1 Antigen test in the first 5 days of fever. After 7-10 days of continuous fever, the recommended test is Dengue fever antibodies IgG & IgM.

Dengue fever may progress to dengue hemorrhagic fever or dengue shock syndrome if left untreated. Dengue hemorrhagic fever (DHF) includes variable manifestations like bleeding, vomiting blood, passing blood in the stool, difficulty breathing, and cold, clammy skin, especially in the extremities. If progressed, the virus may attack blood vessels, causing capillaries to leak fluid into the space around the lungs (pleural effusion) or the abdominal cavity (ascites).

Dengue shock syndrome (DSS) is a severe complication of dengue fever caused when the body's immune system overreacts to the dengue virus. It can lead to a sudden drop in blood pressure and dehydration; if not managed timely, it may lead to multiple organ failures.

There is no specific treatment for dengue, but early diagnostic testing, such as the Dengue Fever NS1 Antigen test, can prevent the advancement of dengue to its complicated forms.

Know more about Dengue Fever NS1 Antigen

Interpreting Dengue Fever Antigen NS1, IgG & IgM results

Interpretations

Result in index	Remarks
Negative (<0.9)	No detectable dengue NS1 antigen. The result does not rule out dengue infection. An additional sample should be tested for IgG & IgM serology in 7-14 days.
Equivocal (0.9-1.1)	Repeat sample after 1 week
Positive (>1.1)	Presence of detectable dengue NS1 antigen. Dengue IgG & IgM serology assays should be performed on follow up samples after 5-7 days of onset of fever, to confirm dengue infection.

Note: Recommended to do NS1 Antigen by ELISA in the first 5 days of fever. After 7-10 days of continuous fever, the recommended test is Dengue fever antibodies IgG & IgM by ELISA.

ANTIBODY DETECTED	REMARKS
IgM	Primary Dengue
IgM & IgG	Late Primary / Early Secondary Dengue
IgG	Secondary / Past Dengue

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Dengue Fever Antigen NS1, IgG & IgM

Frequently Asked Questions about Dengue Fever Antigen NS1, IgG & IgM

Q. Is there any vaccine available for Dengue?

No, there is no vaccine available for Dengue.

Q. What are the symptoms of Dengue fever?

Dengue fever takes around 3 to 7 days to show its effect. Sometimes the infection remains asymptomatic (without symptoms), but the majority of individuals develop classic dengue fever. Symptomatic patients become acutely febrile (feverish) and may develop severe musculoskeletal pain, headache, retro-orbital pain, and a transient macular rash, most often observed in children. Children and young adults remain at increased risk of developing dengue hemorrhagic fever and dengue shock syndrome, particularly after repeated infection with a new Dengue virus serotype.

Q. What is the advantage of detecting dengue NS1 antigen instead of dengue antibodies?

Detection of Dengue NS1 antigen helps in the diagnosis of current infection within the first week of illness (during the fever phase). Detection of IgM antibody, however, indicates possible current infection or recent infection (can be positive if the infection had occurred within the past 2 to 3 months). For medical management of acute fever, it is important to diagnose current infection which is done by Dengue-NS1. It has been observed that detecting Dengue NS1 is way reliable and takes less time than IgM, which takes around 6 to 10 to show results.

Q. Is there any specific treatment available for Dengue?

No, there is no specific treatment or antiviral medicine available for Dengue. The treatment available is mainly supportive which is based on observation of hemorrhagic and circulatory abnormalities and laboratory test results (e.g., electrolytes, platelets, and hemoglobin).

Q. What are the clinical types of Dengue fever?

The types of Dengue fever include Dengue fever or break-bone fever with no serious complications, Dengue hemorrhagic fever with bleeding, low platelet, and fluid loss (plasma leakage) and Dengue shock syndrome with low blood pressure.

Q. How is the blood sample taken?

The healthcare provider takes a blood sample from the arm. The site from where the blood is to be withdrawn is cleaned with a swab of rubbing alcohol. This is then followed by inserting a small needle which has a tube attached to it for collecting blood. Once the sufficient blood for analysis is withdrawn, the needle is removed. The site is then covered with a gauze pad.

Q. Is there any risk associated with the withdrawal of blood sample procedure?

As such there is no risk but in few cases, bruising, bleeding, and infection at the puncture site can be seen. In very few cases, there can be swelling of the vein after the blood is withdrawn.

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